Addex drug candidate effective

Addex Pharmaceuticals / Addex drug candidate effective in osteoarthritispain model processed and transmitted by Hugin AS. The issuer is solelyresponsible for the content of this announcement.

Geneva, Switzerland, 13 July 2010 - Allosteric modulation companyAddexPharmaceuticals Ltd. (SWISS: ADXN) announced today that itspreclinical drugcandidate ADX71943 was effective in a model of osteoarthritis pain.ADX71943 isa makeup brush potent and selective positive allosteric modulator of gamma-aminobutyricacidsubtype B (GABA-B) receptors. GABA-B receptors mediate the slow,prolongedphysiological effects of the inhibitory neurotransmitter GABA and areimplicatedin pain processing. Phase I clinical testing is scheduled to start bythe endof 2010.

"We believe the allosteric mechanism of ADX71943 is the key factorin thedifferentiated tolerability and lack of tolerance development observed inthesepreclinical studies. We look forward to testing this compound in humans,wherewe hypothesize that this product could provide not only a noveltreatment forosteoarthritis pain, but also an important opioid-sparing therapy forotherchronic pain indications," Addex CEO Vincent Mutel said.

The effects of ADX71943 on mechanical hyperalgesia (increased painsensitivity)and mechanical allodynia (pain produced by a normally innocuous stimulus)wereassessed in the monosodium iodoacetate (MIA) model of osteoarthritis, amodel ofchronic nociceptive pain. ADX71943 significantly reduced mechanicalhyperalgesiaand showed a trend toward reducing mechanical allodynia after bothacute andsub-chronic (8 days) dosing. Statistically significant antihyperalgesicactivitywas observed on the first day and was maintained on day 8, despiteincreasedpain severity.

A maximal effect of ADX71943 was already achieved with the lowest dosetested (1mg/kg). The efficacious plasma concentration (corresponding to 1mg/kg) wasapproximately 30-50 ng/mL. Importantly, no development of tolerance wasobservedduring the eight day treatment period.

Addex reported previously that ADX71943 is orally efficacious in rodentmodelsof inflammatory pain (formalin test and Complete Freund's Adjuvant-inducedhypersensitivity) and visceral pain (acetic acid-induced writhing).ADX71943also displays an improved tolerability profile with reduced sideeffectscompared to baclofen.

Baclofen, a marketed generic orthosteric GABA-B receptor agonist, hasshownanalgesic effects in animal models of inflammatory and neuropathic pain.Therealso is some evidence of analgesic activity of baclofen in patientswithneuropathic and cancer pain, although its use in patients is limited by CNSsideeffects.

Addex Pharmaceuticals ( ) discovers and developsallostericmodulators for human health and is focused on validated therapeutictargets fordiseases of the central nervous system, metabolic disorders andinflammation.Subject to the completion of Phase I testing and regulatory approvals,Phase IIclinical trials are expected to start in 2010 in four indications for twoleadproducts: ADX48621, an mGluR5 negative allosteric modulator (NAM), indystoniaand Parkinson's disease levodopa-induced dyskinesia (PD-LID); andADX71149, anmGluR2 positive allosteric modulator (PAM), in schizophrenia andanxiety.ADX71149 is licensed to Ortho-McNeil-Janssen Pharmaceuticals Inc. Inaddition,Merck & Co., Inc. has licensed rights to two preclinical products:mGluR4 PAMfor Parkinson's disease and mGluR5 PAM for schizophrenia. Additionalpreclinicaldiscovery stage programs include: mGluR2 NAM, GLP1R PAM, IL1R1 NAM andTNFR1NAM. Roche Venture Fund and SR-One,
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Add some sparkle to your day

Byline: Sarah Howden

EMBELLISHMENT, in the form of sequins, jewels and crystals has become the latest trend to hit the fashion world. And where once we were told that less is more, the new byword in style is now excess.

According to fashion expert Bonnie Rakhit of Elle Magazine, there are many ways to get the look.

"Embellishment has taken a variety of forms this season, from craft inspired pieces at Chloe and delicate foil dresses at Prada, to Christopher Kane's sporty yet ribbon and jewel emblazoned body conscious dresses and full-on crystal overload at Burberry," she says.

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Edinburgh fashion designer Nicola Melvin agrees. "Clothes embellished with sequins, jewels and crystals are all about making an impact. But you shouldn't be intimidated if you like a more understated look," she says.

"There are all sorts of different interpretations of the trend."

Embellished dresses and tops are the ideal way to glamorise your look in an instant.

But as embellishment continues to be a hot trend for autumn, it's important to buy wisely.

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"Tunics and T-shirt dresses, and other loose fits are big," explains Nicola, "But remember to keep hair, make-up, and all other accessories simple and minimal.

"It's all very well to make an impact but you want it to be in the right way. Try closed-toe shoes and plain coloured tights to balance the look."

But if you prefer a more dressed-down look then eye catching accessories such as large brooches, sparkly ear-rings or jewel encrusted clutch bags are ideal.

Head to Warehouse, Zara, Oli, Matthew Williamson at Debenhams, Oasis, or visit ASOS for accessories and a wide range of clothing designs from those with subtle detailing to designs with more impact. There's no need to relegate embellishment to evening wear as clothes can look on-trend in the daylight hours without looking over the top. The important thing to remember is not to overload the look - choose one embellished item and keep the rest simple.

Go for Marks & Spencer's Limited pink embellished trim tunic and Miss Selfridge's white woven sequin dress, or try on a pretty cardigan or wrap with detailing like Kaliko's white gem embellished cardigan, LK Bennett's sequinned cardigan or Principles black jewel embellished cardigan.

Nicola says: "Embellished accessories also work well Juicy Couture Replica both during the day and night. There is a great selection out there at the moment."

Embellished bags are everywhere at the moment, with some of the best on show at Next, Monsoon, Accessorize, Oasis and Dorothy Perkins.

Try Accessorize for glamorous clutch bags and vintage-style jewellery that appear timeless. And for embellished summer shoes, Brantano's Sophie crystal embellished shoe or Clarks' embellished flip-flops are great options.

But don't do embellished from top-to-toe. Show off your shiny side with clothing or accessories, but don't attempt to over-dazzle or outshine others by wearing them all at the same time. You have been warned.

Edinburgh designer Nicola Melvin is available for commissions via

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Backing OPEC instead of ANWR i

HOUSE SPEAKER Nancy Pelosi opposes lifting the moratorium on drilling in the Arctic National Wildlife Refuge and on the Outer Continental Shelf. She won't even allow it to come to a vote. With $4 gas having massively shifted public opinion in favor of domestic production, she wants to protect her Democratic members from having to cast an anti-drilling, election-year vote. Moreover, given the public mood, she might even lose.

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This cannot be permitted. Why? Because as she explained to Politico: "I'm trying to save the planet; I'm trying to save the planet."

A lovely sentiment. But has she actually thought through the moratorium's actual effects on the planet?

Consider: Twenty-five years ago, nearly 60 percent of U.S. petroleum was produced domestically. Today it's 25 percent. From its peak in 1970, U.S. production has declined a staggering 47 percent. The world consumes 86 million barrels a day; the United States, roughly 20 million. We need the stuff to run our cars and planes and economy. Where does it come from?

Places like Nigeria where chronic corruption, environmental neglect and resulting unrest and instability lead to pipeline explosions, oil spills and illegal siphoning by the poverty- stricken population . Just this week, two Royal Dutch Shell pipelines had to be shut down because bombings by local militants were causing leaks into the ground.

Compare the Niger Delta to the Gulf of Mexico, where deep-sea U.S. oil rigs withstood Hurricanes Katrina and Rita without a single undersea well suffering a significant spill.

The United States has the highest technology to ensure the safest drilling. Today, directional drilling - essentially drilling down, then sideways - allows access to oil that in 1970 would have required a surface footprint more than three times as large. Additionally, the U.S. has one of the most extensive and least corrupt regulatory systems on the planet.

Does Pelosi imagine that with so much of America declared off- limits, the planet is less injured as drilling shifts to Kazakhstan and Venezuela and Equatorial Guinea? That Russia will be more environmentally scrupulous than we in drilling in its Arctic?

Outsourcing U.S. oil production does nothing to lessen worldwide environmental despoliation. It simply exports it to more corrupt, less efficient, more unstable parts of the world - thereby increasing net planetary damage.

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Democrats want no oil from the American OCS or ANWR. But of course they want more oil. From OPEC. From where Americans don't vote. On May 13, Sen. Chuck Schumer - deeply committed to saving just those pieces of the planet that might have huge reserves of American oil - demanded that the Saudis increase production by a million barrels a day. It doesn't occur to him that by eschewing the slightest disturbance of the mating habits of the Arctic caribou, he is calling for the further exploitation of the pristine deserts of Arabia.

The other panacea, yesterday's rage, is biofuels: We can't drill our way out of the crisis, it seems, but we can greenly grow our way out. By now, however, it is blindingly obvious even to Democrats that biofuels are a devastating force for environmental degradation. It has led to the rape of rainforests in Indonesia and Brazil as huge tracts have been destroyed to make room for palm oil and sugar plantations.

There are a dizzying number of economic and national security arguments for drilling at home: a $700 billion oil balance-
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Backing for Nigeria

Phoenix football skipper Andrew Durante remains confident of taking the TAB's money after the first round of World Cup pool matches.

The Phoenix placed two separate $250 multibets, with both returning a possible $20,000.

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"Nigeria is a little bit iffy at the moment but we'll Fashion Loafers Flats see in the second round," Durante said. "We need Nigeria to make it through out of their group but Nigeria lost and South Korea won so they've got to beat them. But everything else is looking all right."

Who is Durante picking to go all the way? "The Germans were very good so probably them and Argentina. I picked Spain all along but they didn't beat Switzerland so Replica chloe Handbags they're struggling a bit."

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Arsene feels the big chill

HAD a chat with Arsene Wenger at Cape Town airport last week.

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He mentioned the Brazil-North Korea game at Ellis Park last week.

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Like the rest of us, his most vivid memory wasn't Elano's goal or the pluck of the North Koreans.

It was the extreme cold and a bitter, bone-chilling wind that took most Europeans by surprise.

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"It was just like being in Sheffield," the Arsenal boss said.

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Art and power in the Central A

Art and power in the Central African savanna; Luba, Songye, Chokwe, Luluwa.

Petridis, Constantijn.

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Cleveland Museum of Art

2008

159 pages

$60.00

Hardcover

NB1255

This generously illustrated oversize (10x12") catalogue was published to accompany an eponymous exhibition organized by the Cleveland Museum of Art and held in various venues during 2008-2009. Petridis, the Museum's African art curator, provides the text, describing and comparing the four cultures. The term fetish has Juicy Couture Bags Replica given way to the more respectful power object to refer to objects carved of wood, in human or animal shape, associated with religious beliefs and the mediation of spirit and human worlds. These objects are conventionally distinguished from art that serves political purposes, but Petridis argues that in Piaget Watches the meticulously made, relatively large-size figures presented here, the two purposes merged. Distributed in North America by Cornell University Press.

([c]2010 Book News, Inc., Portland, OR)

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Brad Hintz, Analyst, Sanford B

(This is not a legal transcript. Bloomberg LP cannot guarantee its accuracy.)

BRAD HINTZ, ANALYST AT SANFORD BERNSTEIN, TALKS TO TOM KEENE AND KEN PREWITT ABOUT GOLDMAN SACHS

APRIL 22, 2010

SPEAKERS: BRAD HINTZ, ANALYST, SANFORD BERNSTEIN TOM KEENE, EDITOR-AT-LARGE, BLOOMBERG NEWS KEN PREWITT, HOST, BLOOMBERG NEWS

07:07

TOM KEENE, EDITOR-AT-LARGE, BLOOMBERG NEWS: Right now, we have the drama kind of securities research, Brad Hintz with us from Sanford Bernstein. Good morning, sir.

BRAD HINTZ, ANALYST, SANFORD BERNSTEIN: Good morning.

KEENE: Buried in your note, wow, on Goldman Sachs. Did the Spitzer Research Analyst Scandal destroy the retail brokerage franchises of Merrill City and Morgan Stanley? No. Did the IPO laddering or spinning cases destroy equity capital franchises like Morgan or Credit Suisse? No. And you suggest Goldman Sachs will survive. Why will they survive?

HINTZ: Well, one, what you're seeing right now is the pullback - the pullback are the discretionary trades. So, yes, do I have to do an equity trade with Goldman? No. Do I have to do an underwriting with Goldman? Do I want to do prime brokerage with Goldman? Absolutely. Do I want to do M&A with Goldman? No question. Do I want an equity underwriting? Yes. So the key, the core businesses, you're not seeing that loss. And so you know are we going to have an impact in terms of clients being nervous? Yes, but it's not going to be long-term impact on a Goldman.

KEENE: Will they get the Ute brain drain? There are people at Goldman not making a kajillion dollars a year. Do they get picked off by the other firms?

HINTZ: There's never any shortage of talent on Wall Street and the NBA's lining up to come into Goldman Sachs. The model of Goldman holds together as long as the partnership holds together. On this one, Replica Breguet we've seen problems before on Wall Street. I don't view this as the end of Goldman.

KEENE: You mentioned equity trading needs a pop here. Is equity trading ready to take the baton? Give us a briefing on that, we don't talk about that now. First, define equity trading.

HINTZ: Equity trading is institutional equity execution and the derivative side. What did surprise us this quarter was that derivatives were so strong at Goldman. Typically, the derivatives books are long volatility and it's in volatility drop this time. It was really a surprise to us that Goldman's derivatives book held up so well. We're going to be going into a slowdown in terms of trade volume, that always happen during the summertime. But we're -

KEENE: I thought Goldman Sachs just worked until like May 1 and then everybody shows up the second week of September. No? No, wait that's Sanford Bernstein that does that. Go ahead, Ken.

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KEN PREWITT, HOST, BLOOMBERG NEWS: Brad, when you look into Goldman's trading for its own account, what did you find out about leverage?

HINTZ: Leverage stayed constant this time. That was actually one of the big surprises that leverage did not go up. VAR went down, which means their performance, their return on risk went up. This was pretty astounding, because Goldman has plenty of room to move their balance sheet up, take leverage up and take performance up. They got 20 percent without having to do that in terms of an ROE.

PREWITT: Did everybody take leverage down after September of '08?

HINTZ: Oh, yes, no question about that
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